Capacity of Lipophilic Auxiliary Substances to Give Spheres by Extrusion-Spheronization
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 19 (7) , 827-842
- https://doi.org/10.3109/03639049309062985
Abstract
The authors consider the preparation of spheroids by extrusion-spheronization with Precirol ato 5 and Gelucire 50/02. The material is a ram extruder and a cylinder extruder associated to a spheronizer. Spheroids are obtained by adding an auxiliary substance such as microcrystalline cellulose. A comparison of the results obtained on the two types of extruder allows a better understanding of the pressure/displacement profile and emphasizes the necessary qualities of the wet mass and extrudates.Keywords
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