FOLLOW UP ON SYSTEMIC INFLUENCE OF PARTIAL PRE‐IRRADIATION ON UV‐TUMORIGENESIS

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Abstract
Abstract— In a previous paper we presented experimental data which showed that partial pre‐irradiation of a mouse enhanced subsequent UV‐tumorigenesis in formerly unexposed skin areas: a systemic effect. In those experiments pre‐irradiation was carried out up to the point where tumors started to appear in the pre‐irradiated skin areas. Here we present the results of an experiment in which pre‐irradiation was discontinued long before the appearance of tumors. The systemic effect induced by the pre‐irradiation remained detectable, though‐it was weaker than in the previous experiment. It is suspected that the observed systemic effect affects the initiation of tumors rather than the growth. A discussion is presented on how changes in initiation may best be detected, which may also prove to be useful for the design of other comparative studies on UV‐tumorigenesis.

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