Forskolin stimulates pinealocyte cGMP accumulation Dramatic potentiation by an α1‐adrenergic → [Ca2+]i mechanism involving protein kinase C
- 5 June 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 249 (2) , 207-212
- https://doi.org/10.1016/0014-5793(89)80625-8
Abstract
The effect of forskolin on cGMP regulation was investigated using dispersed rat pinealocytes. Forskolin stimulated cGMP accumulation in a concentration-dependent manner; this response was strongly potentiated by an α1-adrenergic → [Ca2+]i mechanism involving protein kinase C. These findings provide further evidence that activation of two receptor-regulated signal transduction mechanisms may be commonly required for maximal stimulation of cGMP accumulation, and establish a new experimental approach to the study of cGMP regulationKeywords
This publication has 31 references indexed in Scilit:
- Effect of Forskolin on Voltage-Gated K + Channels Is Independent of Adenylate Cyclase ActivationScience, 1988
- Activators of Protein Kinase C Act at a Postreceptor Site to Amplify Cyclic AMP Production in Rat PinealocytesJournal of Neurochemistry, 1988
- Transmembrane receptor cross-talk: Concurrent VIP and α1-adrenergic activation rapidly elevates pinealocyte cGMP > 100-foldBiochemical and Biophysical Research Communications, 1987
- G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALSAnnual Review of Biochemistry, 1987
- Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylationNature, 1987
- Phospholipase A2 modulation of cyclic GMP metabolism: Characteristics of guanylate cyclase activationLife Sciences, 1985
- Forskolin: From an Ayurvedic Remedy to a Modern AgentPlanta Medica, 1985
- Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytesNature, 1985
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- Multiple Range and Multiple F TestsPublished by JSTOR ,1955