Effect of Fluorohydrocortisone on Gastrointestinal and Renal Excretion of Cations by the Dog.

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Abstract
The daily intramuscular administration of large doses (1 mg/kg) of 9-alpha-fluorohydrocortisone (FF) to intact dogs resulted in a chronic state of polydipsia and polyuria with gross evidence of mild dehydration. With FF treatment the fecal excretion of Na was reduced and that of K enhanced but the converse was true for urinary excretion. These changes did not significantly alter Na balance although serum Na was elevated, but resulted in a negative K balance which was indicated by a drop in serum K and muscular weakness.