THE EFFECT OF STRESS UPON THE KETOSTEROID AND NON-CARBONYL LIPOID CONTENT OF THE ADRENAL CORTEX OF THE RAT*

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Abstract
Adult female rats were stressed with cold, X-ray irradiation, prolonged starvation, intraperit. ACTH given alone, or just prior to stress, and irreversible hemorrhagic shock. The adrenal cortex response to these stresses, excepting hemorrhagic shock, is an initial depletion of ketosteroid, followed by its reaccumulation with return to or toward "normal" pattern within 6 hrs. following cessation of acute stress of short duration. The reaccumulation was only partial in most animals in prolonged starvation. If the stress is prolonged, this return occurs in most animals during the exposure. The depletion and repletion of ketosteroid is most obvious in the fasciculata, much less so in the reticularis. Characteristic changes in the glomerulosa in response to stress cannot be demonstrated. Shifts in ketosteroid content bear an inverse relationship to those in non-carbonyl lipoid. Intraperit. ACTH reproduces the histochemical pattern of acute stress. The "normal" pattern of ketosteroid and non-carbonyl lipoid is not changed by the induction of irreversible hemorrhagic shock in the adult female rat.

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