Local Anti-Inflammatory Properties of Etoclofene. A New Fenamate Derivative

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Abstract
The antiphlogistic effect of topically applied anti-inflammatory drugs was studied on two experimental models of inflammation: the carrageenin-induced paw edema and the croton oil-induced ear edema. Etoclofene, the ethoxymethyl ester of N-(2,6 di-chloro-m-tolyl) anthranilic acid, showed to be as active as acetylsalicylic acid and phenyl-butazone in both tests. Meclofenamic acid, which is chemically very closely related to etoclofene, was less active than etoclofene on the croton oil-induced edema; while benzydamine was inactive in this test. Flufenamic acid and indomethacin showed a local anti-inflammatory activity lower than that of etoclofene on the carrageenin-induced paw edema. Etoclofene applied topically in combination with dexamethasone 17-valerate on edematous paws showed a small additive effect.

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