To the Editor: The article by Schreiber et al. (N Engl J Med 296:1490–1494, 1977) on low-titer cold-hemagglutinin disease is important and may provide new information on a form of hemolytic anemia occasionally seen by hematologists. However, some conclusions made in the paper are not yet completely supported by the data; no doubt the authors have done the work but have not included the data for the sake of brevity.The presence of severe hemolysis with low-titer cold agglutinins, as well as of little hemolysis with higher-titer cold agglutinins, is a well known observation; hence, the statement made regarding . . .