In vivo formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. I.
- 1 January 1976
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 24 (7) , 1502-1505
- https://doi.org/10.1248/cpb.24.1502
Abstract
The route of in vivo formation of 4-formylaminoantipyrine, a new metabolite of aminopyrine, was examined. As a result of gas chromatography-mass spectrometry and 13C-NMR after oral administration of 13C-labeled aminopyrine to man and rats the formylamino group was formed by oxidation of N-methyl side chain of aminopyrine.This publication has 2 references indexed in Scilit:
- Metabolism and excretion of aminopyrine in man.CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- The biochemistry of aromatic amines. 2-Formamido-1-naphthyl hydrogen sulphate, a metabolite of 2-naphthylamineBiochemical Journal, 1966