Binding of several loop diuretics to serum albumin and human serum from patients with renal failure and liver disease.

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Abstract
The binding of the new diuretic piretanide and 2 other diuretics (furosemide and bumetanide) to bovine serum proteins (especially albumin) was studied using the in vitro equilibrium dialysis method. Piretanide and bumetanide, similar to each other in chemical structure, were almost equal in the binding constant to purified albumin, while the binding constant of furosemide was greater than that of the other 2 diuretics. The binding of the loop diuretics in the dilutions of the sera from healthy adults and patients with renal failure or liver disease was studied by the same method. Protein binding of the drugs was markedly reduced in patients with renal failure. The cause could only partly be explained by some structural changes in the serum albumin molecule of these patients and influences of endogenous substances present in serum.

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