The Function of Ac-Globulin in Blood Clotting

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Abstract
Ac-globulin activity of plasma is quite different from that of serum. In serum the activity is comparatively more intense. Thrombin and not Ca ion is responsible for the production of serum Ac-globulin. In clotting, the reaction is started by thromboplastin. The thrombin produced changes plasma Ac-globulin so that it becomes serum Ac- globulin. The latter intensifies the reaction of prothrombin and thromboplastin. Thrombin thus hastens its own formation through an intermediate. This is co-autocatalysis. Neither the serum nor the plasma Ac-globulin can substitute for thromboplastin in the activation of prothrombin in the presence of optimum amts. of Ca.