Mild α-Halogenation Reactions of 1,3-Dicarbonyl Compounds Catalyzed by Lewis Acids
- 26 September 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 67 (21) , 7429-7431
- https://doi.org/10.1021/jo026025t
Abstract
Lewis acid Mg(ClO4)2, combined with NBS, in CH3CN or EtOAc provided mild and fast bromination of 1,3-dicarbonyl compounds. In particular, this protocol could be applied to the α-monobromination of α-unsubstituted β-keto esters. Similar Lewis acid catalysis was also extended to the α-chlorination and iodination of 1,3-dicarbonyl compounds with NCS and NIS, respectively.Keywords
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