Chromosomal assignment of the mouse kappa light chain genes.
Open Access
- 1 June 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (6) , 2735-2739
- https://doi.org/10.1073/pnas.76.6.2735
Abstract
Mouse-hamster somatic cell hybrids containing a variable number of mouse chromosomes have been used in experiments to determine which mouse chromosome carries the immunoglobulin kappa light chain genes. It has been shown by nucleic acid hybridization that the kappa constant gene and the genes for at least one variable region subgroup are on mouse chromosome 6. This somatic cell genetic mapping procedure appears to be general and can be applied to any expressed or silent gene for which an appropriate nucleic acid probe exists.Keywords
This publication has 24 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- The arrangement and rearrangement of antibody genesNature, 1978
- Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.Proceedings of the National Academy of Sciences, 1978
- A complete immunoglobulin gene is created by somatic recombinationCell, 1978
- Assignment of the receptor for ecotropic murine leukemia virus to mouse chromosome 5.The Journal of Experimental Medicine, 1978
- Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis.Proceedings of the National Academy of Sciences, 1978
- Co-transfer of human X-linked markers into murine somatic cells via isolated metaphase chromosomesProceedings of the National Academy of Sciences, 1978
- Chromosomal localization of human β globin gene on human chromosome 11 in somatic cell hybridsProceedings of the National Academy of Sciences, 1978
- Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridizationCytogenetic and Genome Research, 1978
- The IB-peptide Marker and the Ly-3 Surface Alloantigen: Structural Studies of a V -region Polymorphism and a T-cell Marker Determined by Linked GenesCold Spring Harbor Symposia on Quantitative Biology, 1977