Inhibition of cyclic AMP efflux by insect pheromones and fatty acids
- 13 February 1989
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 244 (1) , 149-153
- https://doi.org/10.1016/0014-5793(89)81181-0
Abstract
Avian erythrocytes export cyclic AMP by a means that prostaglandins A1 and A2, but not other eicosanoids, inhibit (EC50 ≈ 45 nM). Several insect pheromones and the fatty acyl components of common membrane phospholipids also inhibit cyclic AMP efflux (EC50 ≈ 3O μM). The presence of at least one double bond in the acyl chain enhances the effect. Unlike PGA, fatty acids probably do not act via formation of a glutathione adduct but very likely by altering membrane fluidity. Inhibition of cyclic AMP export provides a mechanism by which products of phospholipid metabolism can influence the cyclic AMP signaling pathwayKeywords
This publication has 5 references indexed in Scilit:
- Effects of chronic exposure to ethanol on the physical and functional properties of the plasma membrane of S49 lymphoma cellsBiochemistry, 1988
- Effect of double bonds on the dynamic properties of the hydrocarbon region of lecithin bilayersBiochemistry, 1981
- Fatty acids as modulators of membrane functions: catecholamine-activated adenylate cyclase of the turkey erythrocyte.Proceedings of the National Academy of Sciences, 1975
- Influence of fatty acid and sterol composition on the lipid phase transition and activity of membrane-bound enzymes in Acholeplasma laidlawiiBiochimica et Biophysica Acta (BBA) - Biomembranes, 1973
- A Protein Binding Assay for Adenosine 3′:5′-Cyclic MonophosphateProceedings of the National Academy of Sciences, 1970