Prediction of Pocket-Portable and Implantable Glucose Enzyme Electrode Performance from Combined Species Permeability and Digital Simulation Analysis

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Abstract
Development of enzyme electrode sensors can be facilitated by the use of computer simulation modeling techniques. In this work, the model accounts for contacting solution effects, changes in species diffusion and partition coefficients across multiple membrane layer interfaces, cofactor limitation effects, enzyme loading, enzyme kinetics and decay, and other variations in electrode layer geometry. Experimentally determined single species membrane permeabilities are included in the digital simulations to predict the performance characteristics of a multilayered glucose oxidase based enzyme electrode. Information obtained includes range of sensor linearity under different substrate and cofactor concentration combinations, sensor time response and output as permeability parameters and enzyme loading are varied, sensor washout and interference effects, and prediction of decay of sensor enzyme concentration and resultant estimated sensor lifetime as a function of contacting solution conditions and sensor permeability.

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