A light microscopic study of the developing human neural retina

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Abstract
Human embryonic and fetal eyes from 4 mm to 200 mm crownrump length (26 days to 21 weeks of gestation) were studied in 0.75‐μm sections impregnated with silver and toned with gold. The layer of Chievitz was formed by an inward migration of ganglion‐cell and Müller‐cell nuclei from the outer neuroepithelium and then, after further changes in nuclear location, the layer of Chievitz was cleared of ganglion‐cell nuclei to become the definitive inner plexiform layer. Müller‐cell nuclei later populated all retinal layers in the fetus. The argyrophilic Müller‐cell cytoplasm associated with neuronal development is discussed in relation to glia‐neuron interactions, with emphasis on the particular needs of retinal tissue.