Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP 40
- 25 October 1991
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 254 (5031) , 558-562
- https://doi.org/10.1126/science.1683003
Abstract
After antigenic stimulation of T lymphocytes, genes essential for proliferation and immune function, such as the interleukin-2 (IL-2) gene, are transcriptionally activated. In both transient transfections and T lymphocyte-specific in vitro transcription, the homeodomain-containing protein Oct-1 participated in the inducible regulation of transcription of the IL-2 gene. Oct-1 functioned in this context with a 40-kilodalton protein called Oct-1-associated protein (OAP40). In addition to interacting specifically with DNA, OAP40 reduced the rate of dissociation of Oct-1 from its cognate DNA-binding site, suggesting that a direct interaction exists between Oct-1 and OAP40.Keywords
This publication has 28 references indexed in Scilit:
- A novel mediator between activator proteins and the RNA polymerase II transcription apparatusCell, 1990
- New type of POU domain in germ line-specific protein Oct-4Nature, 1990
- Site-directed mutagenesis by overlap extension using the polymerase chain reactionGene, 1989
- Contingent Genetic Regulatory Events in T Lymphocyte ActivationScience, 1989
- A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequenceCell, 1988
- Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivationCell, 1988
- A 100-kD HeLa cell octamer binding protein (OBP100) interacts differently with two separate octamer-related sequences within the SV40 enhancer.Genes & Development, 1987
- A common octamer motif binding protein is involved in the transcription of U6 snRNA by RNA polymerase III and U2 snRNA by RNA polymerase IICell, 1987
- The Interleukin-2 T-Cell System: A New Cell Growth ModelScience, 1984
- E. coli RNA polymerase interacts homologously with two different promotersCell, 1980