In vitro effects of 4-hydroperoxycyclophosphamide on concanavalin A-induced human suppressor T cells
- 31 October 1984
- journal article
- research article
- Published by Springer Nature in Cancer Immunology, Immunotherapy
- Vol. 18 (2) , 113-117
- https://doi.org/10.1007/bf00205744
Abstract
Treatment in vitro of human peripheral blood lymphocytes (PBL) with ConA induced the generation of suppressor cells which inhibited T cell blastogenic response to ConA and of allogeneic response in the mixed lymphocyte reaction (MLR). Treatment of PBL with 4-hydroperoxycyclophosphamide (4-HPCy) before incubation with ConA markedly decreased the generation of suppressor cells by ConA. The effect of 4-HPCy on generation of suppressor cells was more pronounced in the test of ConA stimulation than in the MLR. Treatment with 4-HPCy had no effect on suppressor cells already induced as shown by incubation of PBL with 4-HPCy after incubation with ConA.Keywords
This publication has 11 references indexed in Scilit:
- The immunopharmacology of cyclophosphamidePublished by Elsevier ,2002
- In vitro effects of 4-hydroperoxycyclophosphamide on human immunoregulatory T subset function. I. Selective effects on lymphocyte function in T-B cell collaboration.The Journal of Experimental Medicine, 1982
- Direct in vitro evidence for different susceptibilities to 4-hydroperoxycyclophosphamide of antigen-primed T cells regulating humoral and cell-mediated immune responses to sheep erythrocytes: a possible explanation for the inverse action of cyclophosphamide on humoral and cell-mediated immune responses.The Journal of Immunology, 1981
- Relative susceptibilities of T cell subsets involved in delayed-type hypersensitivity to sheep red blood cells to the in vitro action of 4-hydroperoxycyclophosphamide.The Journal of Immunology, 1980
- Induction in vitro of reversible immunosuppression and inhibition of B cell receptor regeneration by defined metabolites of cyclophosphamideEuropean Journal of Immunology, 1979
- Regulation of delayed‐type hypersensitivity. III. Effect of cyclophosphamide on the suppressor cells for delayed‐type hypersensitivity to sheep erythrocytes in miceEuropean Journal of Immunology, 1978
- Induction of autoreactive T lymphocytes and their suppressor cells by cyclophosphamideNature, 1978
- Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors.The Journal of Experimental Medicine, 1976
- Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses.The Journal of Experimental Medicine, 1975
- Separation of leukocytes from blood and bone marrow. Introduction.1968