Glomerulopathy in swine: microscopic lesions and IgG or C3 deposition in 100 pigs.

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Abstract
Microscopic lesions and deposition of IgG and C3 were examined by light and fluorescent microscopy in the kidneys from 100 slaughtered pigs of about six month-old. Ninety-six pigs had diffuse or focal glomerulopathy. The most common lesions were global or segmental mesangial enlargement due to hypercellularity, increased mesangial matrix and deposits of hyaline materials. In 26 out of 100 pigs, cells containing hyaline globules were present in the mesangium. In a few pigs, these cells accumulated in segments of glomerular tufts, showing mesangiolysis. Ninety-seven pigs had massive and/or granular deposits of IgG predominantly in mesangial areas; one of these pigs had heavy deposits along the glomerular capillary walls. The distribution of specific fluorscence for IgG was diffuse global, diffuse segmental or focal segmental. The kidneys of 98 pigs stained positively for C3 deposit. The location and distribution of C3 were identical to those of IgG. These findings indicate a high incidence of glomerulopathy in swine.