Prothymosin α is a nuclear protein
- 4 January 1988
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 226 (2) , 217-219
- https://doi.org/10.1016/0014-5793(88)81425-x
Abstract
Prothymosin α, a protein first isolated from rat thymus and widely distributed in animal tissues, has an attributed role in the stimulation of the immune system. Its structure contains thymosin α1, a Glu‐rich domain and a putative nuclear location signal. Furthermore, the amount of this protein seems to be associated with the relative size of the nucleus and is inducible during cell growth. We postulate that prothymosin α is located inside the cell nucleus and that its activity might be to organize some protein complexes.Keywords
This publication has 21 references indexed in Scilit:
- Prothymosin alpha in human blood.Proceedings of the National Academy of Sciences, 1987
- Cloning of nucleoplasmin from Xenopus laevis oocytes and analysis of its developmental expression.Genes & Development, 1987
- cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.Proceedings of the National Academy of Sciences, 1986
- Preparations of homeostatic thymus hormone consist predominantly of histones 2A and 2B and suggest additional histone functions.Proceedings of the National Academy of Sciences, 1985
- Parathymosin alpha: a peptide from rat tissues with structural homology to prothymosin alpha.Proceedings of the National Academy of Sciences, 1985
- [17] Prothymosin α and α1-like peptidesPublished by Elsevier ,1985
- [14] Thymosin fraction 5 and 5APublished by Elsevier ,1985
- A short amino acid sequence able to specify nuclear locationCell, 1984
- Cloning and sequence analysis of cDNA for rat spleen thymosin beta 4.Proceedings of the National Academy of Sciences, 1984
- Nucleosome assemblyNature, 1980