STUDIES ON CALIFORNIA ENCEPHALITIS IN MINNESOTA1

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Abstract
Monath, T. P. C. (Arbovirology Unit, NCDC, Atlanta, Ga. 30333), J. G. Nuckolls, J. Berall, H. Bauer, W. A. Chappell and P. H. Coleman. Studies on California encephalitis in Minnesota. Amer. J. Epid., 1970, 92: 40–50.—An extensive serologic survey was conducted in Winona, Minnesota, an area of perennial California group arbovirus activity, to determine the prevalence of past infection with these viruses. Hemagglutination-inhibition, complement-fixation, and neutralization tests using La Crosse antigen were performed on sera of individuals residing in urban and rural areas. Of the rural population, 13.0% had HI and 26.8% had N antibodies, whereas among urban residents only 4.0% had HI and 15.3% had N antibodies. Large increments in the prevalence of antibodies were found between ages 5–9 years among rural and ages 10–19 years among urban residents. Rural males had a higher prevalence of HI and N antibodies than rural females. No relationship of antibody to sex was noted in the urban group. HI tests on selected sera using California group viruses other than La Crosse indicated possible human infection with the Trivittatus serotype. Clinical infection with California viruses was implicated in one of 23 children with an undifferentiated febrile illness without CNS signs.

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