Hemodynamics During Diazepam Induction of Anesthesia for Coronary Artery Bypass Grafting

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Abstract
The hemodynamics during induction of anesthesia were studied in 10 patients with ischemic heart disease about to have coronary artery bypass grafting. I.v. diazepam, 0.5 mg/kg (with 50% N2O in O2 inspired and pancuronium i.v.), was used to induce anesthesia. Compared to awake baseline, induction caused statistically significant decreases in the mean arterial pressure, rate pressure product, stroke index, and left and right ventricular stroke work indexed. Although statistically significant, the hemodynamic changes were small and transient and required no modifying treatment. This anesthetic induction technique is safe, efficient and well tolerated by patients having myocardial revascularization surgery.