Some Observations on the Pathogenesis of Bartter's Syndrome

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Abstract
ALTHOUGH the association of hyperreninemia, hyperaldosteronism, hypokalemic alkalosis and resistance to the pressor effect of angiotensin in Bartter's syndrome is well recognized,1 2 3 4 5 6 7 8 there is no agreement concerning the primary event leading to this combination of abnormalities. In the patient described below, an attempt was made to elucidate the pathogenesis of the disorder.Case ReportA 35-year-old man, born on April 27, 1937, had tetany, weakness, frequent vomiting and general malaise from infancy until the age of 17 years, when his health improved and his weight began to increase. Aside from polyuria and occasional muscle cramps since childhood and attacks of . . .