OPTIMAL INSULIN INFUSION CONTROL VIA A MATHEMATICAL BLOOD GLUCOREGULATORY MODEL WITH FUZZY PARAMETERS
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Cybernetics and Systems
- Vol. 22 (1) , 1-16
- https://doi.org/10.1080/01969729108902267
Abstract
In this paper, we consider a blood glucose-insulin model subject to parameter variation. Our aim is to use a mathematical optimization technique lo derive insulin infusion programs for the regulation of the blood glucose level in the case of worst possible parameter values. Numerical computation and simulation studies are carried out to verify the performance of the method on regulation of initially high blood glucose level while fasting and of blood glucose level after a meal prior to which blood glucose is at its rest level.Keywords
This publication has 7 references indexed in Scilit:
- Optimal insulin infusion resulting from a mathematical model of blood glucose dynamicsIEEE Transactions on Biomedical Engineering, 1989
- Does Physiological Blood Glucose Control Require an Adaptive Control Strategy?IEEE Transactions on Biomedical Engineering, 1987
- A semi‐closed loop computer‐assisted insulin infusion systemThe Medical Journal of Australia, 1984
- A Review of Programmed Insulin Delivery SystemsIEEE Transactions on Biomedical Engineering, 1981
- Control of hyperglycemia in adult diabetics by pulsed insulin deliveryDiabetes, 1977
- Mathematical analysis of blood glucose and plasma insulin responses to insulin infusion in healthy and diabetic subjectsComputers in Biology and Medicine, 1973
- Model studies of blood-glucose regulationBulletin of Mathematical Biology, 1965