Calcium-Stimulated, ATP-Magnesium-Dependent Inactivation of Pig Liver Glycogen Synthase
- 1 March 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 93 (3) , 939-942
- https://doi.org/10.1093/jb/93.3.939
Abstract
Ca2+-stimulated inactivation of liver glycogen synthase was observed when a partially purified liver phosphorylase kinase fraction containing glycogen synthase was incubated with ATP-Mg2+ The Ca2+ portion of this inactivation was partially counteracted by trifluoperazine and slightly stimulated by exogenously added calmodulin. These results suggest that Ca2+ may be involved as one of the factors causing this glycogen synthase inactivation. Although the exact mechanism mediated by Ca2+ has not been clearly determined, the possibility of the participation of some Ca2+ protein kinase is discussed.Keywords
This publication has 0 references indexed in Scilit: