Serum from infected mice suppresses macrophage-mediated immunity in Mycobacterium lepraemurium infection: a model for impaired macrophage immunity in human leprosy
- 1 January 1979
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 73 (2) , 212-215
- https://doi.org/10.1016/0035-9203(79)90215-3
Abstract
Differing patterns of Mycobacterium lepraemurium infection in inbred strains of mice are of interest as a model system for studying mycobacterial infections of man, e.g. M. leprae, which present with a spectrum of clinical disease. In vitro, macrophages from both resistant (C57B1) and susceptible (BALB/c) inbred strains of mice can be shown to be equally effective in controlling multiplication of M. lepraemurium. Experiments presented here show that in vivo, the potential mechanisms of macrophage-mediated immunity are suppressed in the susceptible (BALB/c) strain of mouse by a soluble factor(s) present in the serum and the peritoneal fluid of infected mice.Keywords
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