Stereochemistry of biosynthesis of the vinyl groups of protoporphyrin-IX: a short synthesis of porphobilinogen

Abstract
Porphobilinogen (1), [2H]-labelled in the propionic residue, is synthesised by a short route and is used to establish that both vinyl groups of protoporphyrin-IX are biosynthesised by overall antiperiplanar elimination of a proton and carbon dioxide.

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