Characterization of two different peptides from the venom of the scorpion Buthus sindicus
- 6 November 1989
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 257 (2) , 260-262
- https://doi.org/10.1016/0014-5793(89)81548-0
Abstract
Two disulfide-rich, low-molecular mass peptides (~3 kDa and ~4 kDa) have been isolated from Buthus sindicus venom using ion-exchange and reverse-phase HPLC. Peptide I has 35 residues with 8 half-cystine residues and is clearly related to four-disulfide core proteins of the neurophysin type and to toxins of other scorpion species (55–63% residue identity). Peptide II, present in low yield, has 28 residues with 6 half-cystine residues and a structure largely dissimilar from that of peptide I and other characterized toxins, although probably still a member of the disulfide core peptide type. Consequently, scorpion venom contains, in addition to toxins characterized before, toxin-like compounds with distant relationships.Keywords
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