Acute Renal Failure Histometrical and Experimental Investigations of Factors Causing Oliguria

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Abstract
The anatomical changes of the kidney in acute renal failure are believed to develop after temporary renal ischemia in the stage of partly recovered renal blood flow. Similar renal changes were also observed in autopsy cases without serious clinical symptoms of renal impairment and without oliguria. Renal secretion was theoretically treated and possible influences of anatomical changes on urine volume discussed from data on histometric investigation. Dilatation of tubular lumen was regarded to be one of the factors which reduces urine volume. No difference in renal secretory activity was indicated by the histometric comparison of oliguric and non-oliguric groups. Quantitative evaluation of injuries of the distal tubule revealed a clear correlation of tubular injuries to urine volume and made possible the separation of oliguric and non-oliguric groups.

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