INTRALAMINAR DISTRIBUTION OF CYTOCHROME OXIDASE AND DPN IN RAT CEREBRAL CORTEX

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Abstract
Microchemical techniques were used to determine the quantitative distributions of diphosphopyrldine nucleotide (DPN) and cytochrome oxidase within the architectonic layers of rat somatosensory isocortex. Both the concentration of DPN and the activity of cytochrome oxidase are high, relative to immediately adjacent zones, in layers IIa, IIIb-IV, and Vc. The intracortical distributions of these respiratory enzymes indicate that in cerebral cortex the rate of biological oxidations is highest in layers n, III, and IV. Analysis of the architectonic distribution patterns in terms of the anatomical fine structure of this cortical area shows them to be consistent with localization of DPN and cytochrome oxidase principally in the cyto-plasmic particles of the nerve cell bodies and their dendrites.