The dependence of the hemoglobin (beta plus gamma)/alpha chain synthetic ratio on the degree of anemia in beta-thalassemia (38561).

  • 1 February 1975
    • journal article
    • Vol. 148  (2) , 459-62
Abstract
The peripheral blood hemoglobin (beta plus gamma)/alpha chain synthetic ratio in three homozygous beta-thalassemic subjects was shown to increase towards unity as their hematocrits were raised by stepwise transfusion. The observation that the chain synthetic ratio can vary in a given individual is discussed in relation to current understanding about the regulation of hemoglobin synthesis.

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