Enzymic and Chemical Synthesis of ɛ‐N‐(l‐Propionyl‐2)‐l‐Lysine
- 30 September 1978
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 90 (2) , 297-300
- https://doi.org/10.1111/j.1432-1033.1978.tb12603.x
Abstract
Pyruvate acted as an oxo acid substrate in the reverse direction of [bakers yeast] saccharopine dehydrogenase [EC 1.5.1.7] [.epsilon.-N-(L-glutaryl-2)-L-lysine: NAD oxidoreductase (L-lysine-forming)] reaction. The enzymic condensation product of lysine and pyruvate was isolated and identified as .epsilon.-N-(L-propionyl-2)-L-lysine by comparison with the synthetic compound. A method for the chemical preparation of diastereoisomers of .epsilon.-N-(propionyl-2)-L-lysine is also described.Keywords
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