The Effect of Para-Aminobenzoic Acid on the Serum Cholesterol Level in Man

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Abstract
Serum cholesterol levels in thirteen male subjects were determined during periods of medication with para-aminobenzoic acid at a dosage of 8 gm. daily. The average control value of 240.3 mg./100 ml. fell to 212.6 mg./100 ml. during the period of medication, a fall of 11.5 per cent. This change, while of limited significance, was not seen following administration of benzoic acid in a comparable manner. In an attempt to determine possible mechanisms responsible for this difference the conjugation of bile acids in bile was studied. Following the administration of para-amino-benzoic acid and also nicotinic acid, there was an increase in the proportion of taurine to glycine conjugated bile acids. An opposite effect followed the administration of benzoic acid.