Studies on somatostatin with time‐resolved spectroscopy and molecular dynamics simulations
- 31 August 1990
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 36 (3) , 297-301
- https://doi.org/10.1111/j.1399-3011.1990.tb00982.x
Abstract
Somatostatin was studied by time-resolved fluorescence spectroscopy and by molecular dynamics simulations. The results obtained indicate the existence of mainly one conformation in DMSO, and the existence of several conformations in other solvents. Molecular dynamics simulations showed that the most important region for activity (residue 7-9) is also the most flexible region in the peptide.Keywords
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