Effect of Stimulation of the Cerebellum on Insulin Secretion

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Abstract
The cerebellar cortex of dogs anesthetized with thiopental was electrically stimulated under direct vision. Pancreatic venous plasma was analyzed for insulin-like activity using hypophysectomized, adrenalectomized rats before, during and after the stimulation. A significant decrease in the secretion of insulin following an intravenous load of glucose was invariably observed during stimulation of the vermal part of the cerebellar anterior lobe, and this inhibitory response was abolished by local cocainization of the cortex. Stimulation of the posterior vermal lobe induced no marked alteration in the rate of secretion of insulin-like substances. In the absence of a glucose load, the basal level of insulin-like activity did not change appreciably during and after stimulation of the anterior or posterior vermal lobe. (Endocrinology74: 361, 1964)

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