CLINICAL-TRIAL DEPLETING LYMPHOCYTES-T FROM DONOR MARROW FOR MATCHED AND MISMATCHED ALLOGENEIC BONE-MARROW TRANSPLANTS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 69  (4) , 377-386
Abstract
Nine patients received T-lymphocyte-depleted histocompatible bone marrow and 28 patients received T-lymphocyte-depleted histoincompatible bone marrow. Eight of 9 patients receiving matched bone marrow quickly engrafted without severe graft-vs.-host disease (GvHD). None of the 8 patients received anti-GvHD prophylaxis medications. Two of these 8 patients are currently alive. Nonengraftment and severe GvHD were problems seen in some of the patients given the histoincompatible bone marrow. Additional cytarabine pretransplant permitted engraftment in those patients undergoing histoincompatible transplants for treatment of malignancy and prednisone and cyclosporine posttransplant reduced the incidence of acute GvHD in those given T-lymphocyte-depleted grafts. Seven of these 28 patients are currently alive. T-lymphocyte-depleted marrow can reduce the occurrence or prevent severe acute GvHD, especially when combined with additional prednisone and cyclosporine. However, the impact on relapse patterns and survival remains to be determined. The occurrence of nonengraftment and treatment-related lymphomas are formidable problems to overcome.

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