Blood glutathione and non-glucose reducing substances in diabetes

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Abstract
Total and reduced blood glutathione were determined in 20 normal and 39 diabetic persons. A significant reduction in glutathione was found only in the diabetics with severe ketosis. This reduction may be related to the reduction of base in diabetic ketosis. The blood glutathione content was compared with the difference between the concn. of "true" glucose and total reducing substances. Glutathione does not always account for this difference, which suggests that other reducing substances not yet identified must be present in the blood.