A safe and fast-acting surgical anesthetic for use in the guinea pig
- 1 March 1975
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 38 (3) , 538-539
- https://doi.org/10.1152/jappl.1975.38.3.538
Abstract
Ketamine [dl-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone] hydrochloride was used in conjunction with Acepromazine [10–3-(dimethylamino)-propyl]phenothiazin-2-yl-methyl ketone] Maleate to produce surgical depth anesthesia in guinea pigs. In tests with 97 animals, an intramuscular injection of 44 mg/kg ketamine hydrochloride plus 2 mg Acepromazine Maleate was found to be effective in producing a surgical level of anesthesia within 2 min after administration. The anesthetic state lasted for an average of 1.5 h and could be safely extended by supplemental administrations of the drugs. This anesthetic combination was found to be fast acting, safe, and easily controlled.Keywords
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