Peripheral injury enhances central regeneration of primary sensory neurones
- 1 June 1984
- journal article
- Published by Springer Nature in Nature
- Vol. 309 (5971) , 791-793
- https://doi.org/10.1038/309791a0
Abstract
The success of peripheral and fetal neural tissue in promoting outgrowth of axons from the adult mammalian central nervous system has tended to focus attention on local interactions between extending axons and their environment. The contribution to axon regeneration of biochemical and morphological changes in injured neurones is more difficult to evaluate. We report here that long spinal axons of primary sensory neurones are 100 times more likely to regenerate into peripheral nerve grafts if their peripheral axons are also cut. Regenerative behaviour at the axon tip seems to be strongly influenced by inducible events in the nerve cell.Keywords
This publication has 24 references indexed in Scilit:
- Regeneration of long spinal axons in the ratJournal of Neurocytology, 1984
- Protein Synthesis and Rapid Axonal Transport During Regrowth of Dorsal Root AxonsJournal of Neurochemistry, 1983
- Peripheral nerve autografts to the rat spinal cord: Studies with axonal tracing methodsBrain Research, 1982
- Extensive elongation of axons from rat brain into peripheral nerve graftsNature, 1982
- Protein Synthesis and Axonal Transport During Nerve RegenerationJournal of Neurochemistry, 1981
- Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systemsThe Journal of cell biology, 1981
- Regeneration of the septohippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridgesBrain Research, 1981
- Axons from CNS neurones regenerate into PNS graftsNature, 1980
- Regeneration of monoaminergic and cholinergic neurons in the mammalian central nervous systemPhysiological Reviews, 1979
- Reactions of dorsal root ganglion cells to section of peripheral and central processesJournal of Comparative Neurology, 1940