Biological Assay of Proteolytic Enzymes Capable of Debriding Third Degree Burn Eschars
- 1 May 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 107 (1) , 79-83
- https://doi.org/10.3181/00379727-107-26541
Abstract
Summary A semi-quantitative bioassay has been described for determining the ability of proteolytic enzymes to debride third degree burn eschars on guinea pigs. With the aid of statistical designs, body weight and site of application were established as the 2 most important experimental variables. Trypsin, a highly purified mold enzyme, and 2 proteinase preparations from C. histolyticum have been compared for their ability to debride contact burns. pHisoHex was found to inhibit the 0-22% proteinases.Keywords
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