AGGREGATION OF BLOOD-PLATELETS AND INCREASED HYDRAULIC CONDUCTIVITY OF PULMONARY EXCHANGE VESSELS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 98  (2) , 175-184
Abstract
Pulmonary microembolization secondary to platelet aggregation was suggested to be a pathogenetic component of the shock lung syndrome. Platelets can release factors with a permeability-enhancing activity. The effect of collagen-induced platelet aggregation on the hydraulic conductivity of the exchange vessels in isolated, blood-perfused rabbit lungs was studied. The net rate of fluid filtration in each pair of lungs was determined during standardized elevations of left atrial pressure before and after platelet aggregation induced by intraarterial collagen infusions. Such infusions were followed by a significant, but transient increase in the net rate of fluid filtration. These lungs were papaverinized so that collagen infusions caused only minor increases in inflow pressure. The observed increase in pulmonary arterial pressure could not explain the increase in net filtration rate after collagen infusion. When platelet-poor plasma was used as a perfusate no change in the net rate of fluid filtration was observed after collagen infusion. Intravascular platelet aggregation induced by collagen infusion caused a transient increase in the permeability of the pulmonary exchange vessels.

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