Sequential Sampling in Epidemiology

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Abstract
A sequential procedure is one in which the observations, or pairs of observations, are taken one at a time. Following each observation, or pair, a decision is reached as to whether the data on hand are sufficient to justify a conclusion without further observations. Such procedures produce, on the average, a substantial saving in sample size. Sequential methods have found wide application in laboratory work. In epidemiologic field studies, ethical and administrative considerations, multiplicity of variables observed, as well as the time factor in making the observation, impose some limitations. However, the methods are potentially of great usefulness.
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