THE PROTEIN CONTENT OF THE EXTRACELLULAR FLUID IN NORMAL SUBJECTS AFTER VENOUS CONGESTION AND IN PATIENTS WITH CARDIAC FAILURE, ANOXEMIA, AND FEVER 1

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Abstract
The filtrate from the capillaries of the skin and subcut. tissues normally contains some protein. On the avg., it does not contain more than 0.24 g. % of protein. It probably contains much less. Elevation of the venous pressure in the leg to a level equal to 30 mm. Hg. produces edema which contains from 0.4-1.3 gs. % of protein with an avg. of 08 g. %. Cardiac failure does not make the capillaries of the leg more permeable to protein. Generalized anoxemia sufficient to cause impaired cerebral function does not cause increased permeability of capillaries in the leg. Although local ischemia produces capillary damage and leakage of protein, generalized stagnant anoxia of a degree compatible with life does not make the capillaries of the leg more permeable to protein. Fever and acute infectious disease cause no abnormal increase in permeability to protein in the capillaries of the leg.

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