THE EXPRESSION OF PNA-LECTIN BINDING-SITES AND S-100 PROTEIN IN HISTIOCYTIC LESIONS OF THE SKIN - A COMPARATIVE IMMUNOHISTOCHEMICAL STUDY

  • 1 January 1988
    • journal article
    • research article
    • Vol. 68  (1) , 1-7
Abstract
In this work the potential usefulness of antibodies to S-100 protein and the lectin Peanut Agglutinin (PNA) in the differential diagnosis of histocytic lesions of the skin was assessed. Out of 54 deparaffinized specimens studied through an avidin-biotin-alkaline phosphatase technique, 35 proved to comprise S-100 (+) and 12 PNA (+) cells. The results show that antibodies to S-100 protein are useful in distinguishing the "X" (Langerhans'' cell) from the "non-X" types of histiocytosis, and cast some shadow on the usefulness of the lectin PNA as a histiocytic marker.

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