Antitumor Activity of Killed Corynebacterium parvum Suspensions in a Murine Mammary Adenocarcinoma (CaD2) System2
- 1 June 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 56 (6) , 1171-1175
- https://doi.org/10.1093/jnci/56.6.1171
Abstract
We studied the antitumor activity of killed Coryne-bacterium parvum on the CaD2 mammary adenocarcinoma in DBA/2 mice. Intratumor treatment had little or no effect on subcutaneous tumor growth. Admixture of tumor cells with C. parvum before inoculation completely suppressed tumor growth. No tumor transplantation immunity was detected in mice inoculated with admixtures of C. parvum and tumor cells, but tumors were enhanced under certain circumstances. Growth of a tumor inoculated sc or iv was consistently retarded after iv or ip C. parvum therapy, but tumors rarely regressed. Tumor transplantation immunity was detected in mice treated iv with C. parvum before surgical excision of established tumors. Certain adverse effects of iv or ip administration of C. parvum were also discussed.Keywords
This publication has 1 reference indexed in Scilit:
- Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts.British Journal of Cancer, 1966