Enlarged lymph glands removed from 4 cases of Hodgkin''s disease were subjected to the test devised by Gordon, yielding 3 typically positive, 1 doubtful, and 1 negative result. This syndrome of paralysis, ataxia, and muscular wasting in rabbits on intracerebral (frontal or occipital) plus intravenous inoculation with Hodgkin''s tissue cannot be elicited by the introduction of normal, lymphosarcomatous, leu-kemic, or tuberculous lymphatic tissue. Neither can it be brought about by the intracerebral inoculation of dead bacteria (Bacillus typhosus), streptococcal toxin, sterile milk, peptone water, aleuronat, Na nucleate, quinine urethane, or finely powdered glass.