Effect of ethionine on the rough endoplasmic reticulum from male and female rat liver
- 1 December 1977
- journal article
- research article
- Published by Springer Nature in Molecular Biology Reports
- Vol. 3 (6) , 459-466
- https://doi.org/10.1007/bf00808388
Abstract
Ethionine causes a decrease in the amount of rough endoplasmic reticulum in rat liver, the effect being greater in female than in male rats. Rough endoplasmic reticulum isolated from rat liver 24 hr after ethionine injection and stripped of its ribosomes partially lost itsin vitro ribosome binding capacity. However, no differences were detected between the binding affinities of ribosomes, isolated from either untreated animals or intoxicated rats, to stripped rough membranes derived from normal rats. Structural changes occur in the rough endoplasmic reticulum of the ethionine treated rats, while the ribosomes are still bound to the membrane.Keywords
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