Effect of Conformational Preorganization of a Three-Armed Host on Anion Binding and Selectivity
- 28 October 2002
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 8 (21) , 4946-4956
- https://doi.org/10.1002/1521-3765(20021104)8:21<4946::aid-chem4946>3.0.co;2-v
Abstract
A set of three‐armed urea‐containing anion receptors was prepared. The receptors all have the same binding topology but differ in the level of conformational preorganisation with respect to the arrangement of the side‐arms relative to the platform and within the side arms themselves. This is mirrored in a specific increase (×2.5) in the binding constant for chloride and in a 12‐fold increase in the chloride/nitrate‐selectivity.Keywords
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