Chemical Modification of Validamycin A

Abstract
The chemical modification of validamycin A was examined. One of the synthetic validamycin analogs, N[(1S)-(1,4,6/5)-4,5,6-trihydroxy-3-hydroxymethyl-2-cyclohexenyl] [O-β-2-amino-2- deoxy-d-glucopyranosyl-(1-> 3)-(1S)-(1,2,4/3,5) -2,3,4- trihydroxy-5-hydroxymethyl-cyclohexy] amine monohydrochloride had almost the same activity against the sheath blight of rice plants as that of validamycin A. Partial synthesis of validamycin A was also examined.

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