THE MECHANISM OF ACTION OF THE TUMOUR SUPPRESSOR GENE PTEN
Open Access
- 1 November 2003
- journal article
- review article
- Published by Palacky University Olomouc in Biomedical Papers
- Vol. 147 (1) , 19-25
- https://doi.org/10.5507/bp.2003.003
Abstract
Intracellular levels of phosphorylation are regulated by the coordinated action of protein kinases and phosphatases. Disregulation of this balance can lead to cellular transformation. Here we review knowledge of the mechanisms of one protein p...Keywords
This publication has 40 references indexed in Scilit:
- The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapySeminars in Oncology, 2001
- The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C TerminusJournal of Biological Chemistry, 2001
- Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinaseBiochemical Journal, 2000
- Crystal Structure of the PTEN Tumor SuppressorCell, 1999
- High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceCurrent Biology, 1998
- Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTENCell, 1998
- Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTENScience, 1998
- Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersNature Genetics, 1997
- PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate CancerScience, 1997
- Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BNature, 1995