Transformation of a Rat Epithelial-Like Cell Line by Murine Sarcoma Virus
- 1 August 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 49 (2) , 379-386
- https://doi.org/10.1093/jnci/49.2.379
Abstract
The transformation of an epithelial-like Sprague-Dawley rat line (RL) by the Harvey strain of murine sarcoma virus (MSV-H) was studied. The transformed cells were fibroblastic. Two types of transformed clones were isolated with respect to virus release: one releasing virus immunologically similar to MSV-H, and the other releasing no virus detectable by infectivity or 3H-uridine labeling. The nonproducer transformed cells developed into sarcomas in newborn Sprague-Dawley rats.Keywords
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